Our Careers

• Job Type: Full time
• Start Date: ASAP

Benefits: Our competitive package includes income protection, pension, private health insurance, and life assurance, as well as an opportunity to participate in the Company’s incentive shares scheme.

We are looking for an Analytical Associate to join the fast-growing team within our Translation unit at our site in London! This position is a full-time opportunity, on a permanent basis.

In this role you will support the day-to-day development and implementation of assays and analytics characterising genetically engineered macrophages for therapeutic applications in liver cirrhosis. You will work very closely with the Scottish National Blood Transfusion Service (SNBTS), with which Resolution has partnered to deliver gene-modified macrophage cell therapy for clinical use, to develop a GLP-suitable process.

• • Key Responsibilities:
• •Execution of day-to-day in-process and final product analytical testing required during the process development projects of the Translation group, with focus on cell count, flow cytometry, cell-based functionality assays/co-cultures, proliferation assays, qPCR and metabolic assays•Execution of study protocols for the development of assays and analytics to assess and confirm cell-based product characteristics, including flow cytometry, ELLA, MSD, cell imaging, primary cell culture and co-cultures
• •Execution of study protocols for the development of assays and analytics to assess molecular-based product characteristics, including qPCR to assess product purity and gene expression levels, plasmid copy number and karyotyping
• •Assist in the establishment, development and execution of stability studies
• •Provide input to the compilation of study protocols and reports associated with the development or characterisation of a cell-based or molecular assay
• •Provide input to the documentation for qualification or validation of assays
• •Interfacing with the Cell Engineering and Macrophage Biology Units to support the translation of research protocols and support development of standard operating procedures for the GLP environment
• • Please note that this list is not exhaustive

You will be expected to work as part of a team with Analytical Scientists and others both within and beyond the Translation unit, reporting directly to the Group Leader.

1. Your Qualifications and Experience

   Essential

   • •A Bachelor degree in Biology, Biochemistry or a related discipline
   • •Experience in analytics, including with gene-modified cell therapy products
   • •Experience in Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) settings
   • •Proven track record in development and validation of cell and gene-based assays
   • •Experience with cell flow cytometry, the associated data analysis
   • •Experience with ELISA
   • •Experience with primary cell culture and coculture systems
   • •Experience with molecular techniques, such as qPCR
   • •Proven ability to work productively within a team
   • •Ability to take initiative and work independently

• Preferable

  1. •A working knowledge of immunology and chronic inflammatory diseases, preferably chronic liver disease
  2. •Experience developing cell therapies
  3. •Experience using the CliniMACS Prodigy instrument and associated equipment
  4. •Experience in a commercial laboratory environment/small biotechnology company with a focus on developing cell therapies or ATMPs

1. Selection Process:
2. Following your application, an initial call will be scheduled by the Recruitment Partner before being shortlisted. If successful, you will be invited to start the interview process which consists of 3 stages:
   1. 1. 1. Initial meeting with the Hiring Manager and another member of the RTx team
      2. 2. Presentation & panel interview
      3. 3. Conversation with the CEO

   Please be aware that due to the volume of applications, feedback will not be provided at the application stage.

   For this vacancy, please direct any questions and CVs in the first instance to our Recruitment Partner at Life Science People, Poppy Boronat (poppy.boronat@lifesciencepeople.co.uk).

   1. • Alternatively, apply through the link below.

• Job Type: Full time
• Start Date: ASAP

Benefits: Our competitive package includes income protection, pension, private health insurance, and life assurance, as well as an opportunity to participate in the Company’s incentive shares scheme.

We are looking for a Process Associate to join the fast-growing team within our Translation unit at our site in London! This position is a full-time opportunity, on a permanent basis.

In this role you will support the day-to-day development of a process to produce genetically engineered macrophages for therapeutic applications in inflammatory organ damage. You will work very closely with the Scottish National Blood Transfusion Service (SNBTS), with which Resolution has partnered to deliver gene-modified macrophage cell therapy for clinical use, to develop a GMP-compliant process

• • Key Responsibilities:
  • •Supporting optimisation of established processes suitable for transfer to GMP manufacturing environment for engineered macrophage cell therapy and contribute to SOP development for these procedures
  • •Contributing to analysis of data for use in project reports and presentations
  • •Working closely with Cell Engineering, Macrophage Biology iPSC units to perform technology transfer from research to GMP-compliant processes
  • •Liaising with external contributors and collaborators for harmonisation of workflows and procedures
  • •Maintaining a clean laboratory environment including stock and inventory checks of process specific consumables
  • •Contributing to Translation activities required for dossier development
  • •Maintaining good documentation practices for data recording
  • •Liaising with external vendors and suppliers
  • Please note that this list is not exhaustive

You will be expected to work as part of a team with Process Scientists as well as others within and beyond the Translation unit, reporting directly to the Group Leader.

1. Your Qualifications and Experience

   Essential

   • •A bachelor’s degree in Biology, Biotechnology, or a related discipline
   • •Experience in Good Manufacturing Practice (GMP)/Good Clinical Laboratory Practice (GCLP) settings
   • •Experience in cell therapy process development or manufacture
   • •Experience with different primary cell cultures and different culture systems including differentiation especially iPSC culture to terminal differentiation
   • •Experience using the CliniMACS Prodigy instrument and/or similar equipment
   • •Experience using bioreactors, preferably with experience in manufacturing process scale up
   • •Proven ability to work productively within a team as well as the ability to take initiative and work independently
   • •Excellent time management and organisation
   • •Confidence to communicate effectively and clearly both verbally and in writing

• Preferable

  1. •A working knowledge of immunology and chronic inflammatory diseases, preferably chronic liver disease
  2. •Experience in cell therapy process analytics
  3. •Experience with multicolour cell flow cytometry and associated data analysis
  4. •Experience with ELISA and MSD
  5. •Experience with molecular techniques, such as PCR
  6. •Understanding of Quality Management Systems

1. Selection Process:
2. Following your application, an initial call will be scheduled by the Recruitment Partner before being shortlisted. If successful, you will be invited to start the interview process which consists of 3 stages:
   1. 1. 1. Initial meeting with the Hiring Manager and another member of the RTx team
      2. 2. Presentation & panel interview
      3. 3. Conversation with the CEO

   Please be aware that due to the volume of applications, feedback will not be provided at the application stage.

   For this vacancy, please direct any questions and CVs in the first instance to our Recruitment Partner at Life Science People, Poppy Boronat (poppy.boronat@lifesciencepeople.co.uk).

   1. • Alternatively, apply through the link below.

• Job Type: Full time
• Start Date: ASAP
• Benefits: Our competitive package includes income protection, pension, private health insurance, and life assurance, as well as an opportunity to participate in the Company’s incentive shares scheme.

We are looking for a Research Associate to join the fast-growing team within our Macrophage Biology unit at our site in Edinburgh! This position is a full-time opportunity, on a permanent basis. In this role you will drive testing and development of enhanced macrophage products for cell therapy for liver cirrhosis, taking on a critical role in execution of the company’s research plan.

• • Key Responsibilities:
  • • Validating and deploying assays to test key biological functions of genetically modified (GM) macrophages
  • • General laboratory management and instrument maintenance duties
  • • Working with senior members of the team to develop an accurate record of sample archived during experiments
  • • Interfacing with the Cell Engineering, In Vivo Pharmacology, and Induced Pluripotent Stem Cell units to identify best-in-class GM macrophage products, as well as the Process Development team to assist with writing standard operating procedures and implementing analytics under GMP conditions
  • • Assisting with writing patents, publications, progress reports and presentations
  • Please note that this list is not exhaustive
• You will be expected to work as part of a team with like-minded Research Associates and collaborate closely with a Research Scientist within the same unit, reporting directly into the Director of Macrophage Biology.

1. Your Qualifications and Experience

   Essential

   • • A bachelor’s degree in biology, Biochemistry or a related discipline
   • • 3+ years lab experience
   • • Full proficiency in flow cytometry
   • • Experience with primary immune cell culture, preferably monocytes/macrophages
   • • Experience in molecular biology techniques such as nucleic acid extraction and purification, PCR and qPCR
   • • Experience with antibody-based sorting and analysis using FAC-Sorting and magnetic bead separation (MACS or similar)
   • • Experience in western blotting, ELISA, and immunofluorescence
   • • Ability to maintain accurate and up to date records
   • • Excellent writing, communication, time-management, and interpersonal skills
   • • Willingness to learn and positive attitude and team working
   • • Good computing skills and familiarity with Microsoft Office suite

• Preferable

  1. • A working knowledge of inflammation
  2. • Experience in histology techniques
  3. • Experience in a commercial laboratory environment
  4. • Experience with cloning and transfection
  5. • Familiarity with the principles of Good Clinical Practice (GCP) and Good Manufacturing Practice (GMP) and writing of standard operating procedures

1. Selection Process:
2. Following your application, an initial call will be scheduled by the Recruitment Partner before being shortlisted. If successful, you will be invited to start the interview process which consists of 3 stages:
   1. 1. 1. Initial meeting with the Hiring Manager and another member of the RTx team
      2. 2. Presentation & panel interview
      3. 3. Conversation with the CEO

   Please be aware that due to the volume of applications, feedback will not be provided at the application stage.

   For this vacancy, please direct any questions and CVs in the first instance to our Recruitment Partner at Life Science People, Poppy Boronat (poppy.boronat@lifesciencepeople.co.uk).

   1. • Alternatively, apply through the link below.

• Job Type: Full time
• Start Date: ASAP
• Benefits: Our competitive package includes income protection, pension, private health insurance, and life assurance, as well as an opportunity to participate in the Company’s incentive shares scheme.

We are looking for an experienced Research Scientist to join the fast-growing team within our IVP unit at our site in Edinburgh! This position is a full-time opportunity, on a permanent basis.

In this role you will lead a project to develop and utilise non-invasive imaging methods to understand the pharmacokinetic properties of various macrophage-based cellular products in vivo. Using in vivo and ex vivo technical expertise, the candidate will be expected to establish clinically-relevant imaging methods that could be used to track cells in rodent models with a view to understand the distribution, abundance, and persistence of cell-based therapies in tissues.

• • • • Key Responsibilities:
      • • Identify, develop, and optimise direct and indirect in vitro labelling techniques that permit non-invasive tracking of macrophage-based products in vivo
      • • Ascertain the biocompatibility of labelling methods on macrophage viability, phenotype, and function
      • • Utilising local technical expertise, develop and establish a non-invasive imaging modality to track macrophage-based cellular products in rodent models of health and disease
      • • If and when applicable, adhere to local guidelines, limits, and safety processes for the use, handling, transportation, and disposal of radiotracers
      • • Working with Director In vivo Pharmacology, liaise with technical, clinical, and regulatory experts to facilitate the translation of non-invasive imaging methods to support a potential imaging clinical trial
      • • Support research activity within the IVP unit during safety and efficacy studies to support the progression of macrophage-based cellular products towards clinical evaluation
      • • Seek opportunities to test the feasibility for the establishment of non-invasive methods to quantify collagen content in rodent models of fibrotic liver disease
      • • Applying experience and creativity to overcome research challenges, including refinement of protocols to render fit-for-purpose, troubleshooting of assays, and development and implementation of non-invasive imaging methods for in vivo cell tracking experiments
      • • Establishing and maintaining a robust animal welfare environment to ensure compliance with the Animal (Scientific Procedures) Act 1986 as per Home Office regulations
      • • Performing laboratory-based experiments to measure parameters of fibrosis, injury, and inflammation in animal-derived tissue and biofluid specimens
      • • Maintaining excellent record keeping of all research activities, including up-to-date lab books, writing standard operating procedures, and cataloguing biological specimens and reagents
      • • Interfacing with the Cell Engineering, Macrophage Biology, and Induced Pluripotent Stem Cell research units to streamline in vivo research activities and optimise engineered macrophage candidates under development
      • • Writing patents, publications and summarising data for progress reports and presentations; delivering presentations
      • Please note that this list is not exhaustive
        

        Your Qualifications and Experience

        Essential

        • • A PhD in pharmacology, immunology, biochemistry or other equivalent discipline
        • • 5+ years of experience in using one or more non-invasive imaging technique (e.g. PET, SPECT, MRI) to conduct independent in vivo research with rodents, ideally in a cell and gene therapy application (can include experience as a PhD candidate)
        • • Experience of animal handling and in vivo techniques i.e., general husbandry, injections (via intraperitoneal, intravenous, and subcutaneous routes), appropriate use of anaesthetics and analgesics, and Schedule 1 techniques
        • • Experience in cell culture (ideally with immune cells) e.g., handling cells using aseptic technique and familiarity with methods to assess viability, phenotype, and function
        • • Experience with standard laboratory techniques, e.g. flow cytometry, qPCR, ELISA, cell death assays (LDH/ATP), immunocytochemistry, immunofluorescence, microscopy
        • • Proven track record of independent manuscript publication and/or patent submission
        • • Ability to maintain accurate and up-to-date records
        • • Excellent oral and written communication skills

        Preferable

        1. • An active, or recently expired Home Office Personal Licence (if expired, within last 5 years)
        2. • A working knowledge of liver biology in health and disease
        3. • Familiarity with rodent models of liver disease
        4. • Experience of working with cell or gene therapies or other ATMP
        5. • Experience of aseptic techniques when working with immunocompromised rodents
        6. • Experience in a commercial laboratory environment
        7. • Experience with primary cell culture, ideally with monocytes/macrophages
        8. • Surgical experience (e.g. PIL C holder)

         

      • Selection Process:
        1. Following your application, an initial call will be scheduled by the Recruitment Partner before being shortlisted. If successful, you will be invited to start the interview process which consists of 3 stages:
           1. 1. 1. Initial meeting with the Hiring Manager and another member of the RTx team
              2. 2. Presentation & panel interview
              3. 3. Conversation with the CEO

           Please be aware that due to the volume of applications, feedback will not be provided at the application stage.

           For this vacancy, please direct any questions and CVs in the first instance to our Recruitment Partner at Life Science People, Poppy Boronat (poppy.boronat@lifesciencepeople.co.uk).

           1. • Alternatively, apply through the link below.

• Reporting to: VP Process Development
• Job type: Full time
• Start date: July 2022
• Incentives: An opportunity to participate in the Company’s incentive share scheme
• Benefits: Competitive package including pension, private health insurance, life assurance and income protection

The role of CMC Project Manager is to provide CMC leadership to Resolution’s three lead therapeutic programmes. As a dedicated CMC leader, the person in this role will have considerable influence on the plans for providing product into clinical studies and building strategy for a robust commercial supply chain.

Key responsibilities
• At a project level, leads the cross functional CMC team including process development, analytical, manufacturing, supply chain, quality, and regulatory. Integrates individual CMC workstreams into an overall CMC delivery team
• Accountable for delivery of product to clinical studies and maintains and owns an overall CMC plan
• Accountable for developing a CMC budget and resource plan for each project and interfacing with the project leader and project manager to ensure CMC requirements and deliverables align with the overall project plan
• Developing a tech transfer plans into manufacturing and plans for a fit for purpose supply chain for clinical and commercial supply
• Key interface to the project team as the single point of CMC accountability influencing the project team regarding CMC requirements and influencing the CMC team regarding project requirements
• Influencing and educating other project team members (including investment stakeholders) in CMC priorities and interdependencies with other functions to ensure effective prioritisation
• As member of the CMC leadership team contributing to setting direction for the overall CMC effort in Resolution

The successful candidate will have the right to work in the UK, able to commute daily to Resolution Therapeutics in London and will have the following qualifications, skills and experience:

Your Experience

• At least 5 years’ (preferred >8 years) experience in CMC development, preferably in cell and gene therapy
• Exceptional matrix leadership capabilities especially as it related to influencing across the organisation and productive conflict resolution
• Organised leader that understands risk-based development and proactively manages and communicates CMC risks and mitigation plans
• Experienced with regulatory processes and understanding of phase appropriate development strategies
• A strategic thinker that can develop short- and long-term CMC plans and communicate them across the organisation

Your Qualifications

Basic

• A Bachelor of Science degree with relevant experience in process development, analytical, or manufacturing of biologics
• Project leadership of fast moving and complex projects in biotech or pharma

Desired

• An advanced degree in Biology, Chemistry, Chemical Engineering, Pharmacy, or related discipline
• Delivered a late-stage project into manufacturing and helped establish the associated supply chain for a cell and gene therapy medicine

Interested in the opportunity? To apply, click on the button below and send us your CV.