Our Careers
Do you like building things in a fast-paced, dynamic environment? If so, Resolution Therapeutics could be your next career move. Check out our vacancies below.
Working with us
We are a diverse team of scientists, business folk and entrepreneurs working together to make the world a better place. We value passion, leadership and intellectual honesty, and we are united by a firm belief that transparency is the key to making good decisions. If these values speak to you, and you think your background and skills could help us on our journey to a brighter future, then please get in touch.
Life at Resolution
No two days are quite the same. One day you may be doing routine experiments, whilst the next day you may be negotiating with suppliers, forging academic partnerships, or presenting your results to the company Board. This dynamism brings great variety and opportunity to each and every role, although of course it also brings some unique challenges. Through transparency and open communication, we support each other through these challenges, thus enabling each and every person at Resolution to develop and flourish in their chosen career path.
Take a look at what some of our staff have to say below.




What our team say
I joined Resolution in January 2021. Starting a new role during the current pandemic, I thought it was going to be a huge challenge, especially “managing” the office and supporting the wider team from my living room. Everyone at Resolution made my transition into the world of science so smooth and welcoming, it has been an absolute pleasure. I have been blessed to have worked in various administrative roles throughout my 30-year career and in all that time, I have not experienced the level of passion and enthusiasm the Resolution team have impressed upon myself and the wider team. The support and respect they have for each other too, it is truly inspirational.
Jane Tweedale
Office Manager
I have always been interested in the application of translational research into the clinic, coming from a background of using stem cells in regenerative medicine and prior to that of using stem cell-derived liver models for disease modelling and high throughput drug screening. Joining Resolution has been an incredible opportunity to develop and deliver novel cell therapy products for tissue repair. By working with a multidisciplinary group of scientists, our team is prepared to generate macrophage-based treatments from the lab to the patient
Jose Meseguer Ripollés
Research Scientist, iPSCs
Working with Resolution Therapeutics has been such a rewarding experience. I joined in early 2021 but I have already learnt and grown much professionally. There are many opportunities to apply my practical knowledge and to learn even more. My colleagues are very devoted and enthusiastic about our products and mission, contributing to a great company culture where I can voice my opinions and receive valuable feedback from my peers
Moony Su (Sheng-Yuan)
Research Associate, Macrophage Biology
Resolution Therapeutics is built on a wealth of knowledge and expertise that forms the base of the technology we are developing. Joining in the early stages, with previous experience in the immunotherapy and regenerative medicine industry, I am excited to see the approach to growth that Resolution is fostering; a strong sense of collaboration between teams, a culture of support for one another, and with longevity of the company at the root of it all. I enjoy the momentum and enthusiasm we have, and the excellent opportunities to expand my scientific skills whilst learning from each other as we work to deliver a novel immunotherapy for tissue repair.
Hollie Bartley
Process Scientist
Latest vacancies
Resolution Therapeutics is an equal opportunity employer committed to diversity and inclusion in the workplace. All applicants will be considered for employment based solely on qualifications, merit, and business needs. It’s what you’re capable of that matters, nothing else!
JOB TITLE: R&D Project Manager
LOCATION: London, UK
- Job type: Full time
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection
The role of R&D Project Manager is to provide project management support and leadership to Resolution’s three lead therapeutic programmes ensuring that detailed planning is in place and that progression of the programmes is managed proactively and effectively. As the first dedicated project manager at Resolution the individual will have significant opportunity to shape project and portfolio management within the company and develop best practices for planning and resourcing projects.
Key responsibilities
• Build and maintain project plans for the three key Resolution R&D projects
• Set up, agenda setting and running of project team meetings for each project/project lead
• Support the project leads in all aspects of planning, proactively identifying areas of further planning required and ensuring this is undertaken
• Supporting review of projects at governance boards
• Maintaining effective risk registers and proactively managing and mitigating risks
• Supporting the development of project budgets and requests for further funding
The successful candidate will have the right to work in the UK, able to commute daily to Resolution Therapeutics in London and will have the following qualifications, skills and experience:
Your Qualifications and Experience
Essential
• Degree educated (in biology, chemistry or related discipline)
• In-depth knowledge of the drug research and development process
• Significant (>3 years) experience as a project manager within the pharmaceutical industry
• Significant stakeholder management experience with a track record of proactively identifying issues and risks and driving the discussions necessary to resolve them
• Ability to work independently with minimal supervision and direction
Desired
• Formal project management qualification (PRINCE2 or similar)
Interested in the opportunity? To apply, click on the button below and send us your CV.
ApplyJOB TITLE: CMC Matrix Leader - Translation
LOCATION: London, UK
- Reporting to: VP Process Development
- Job type: Full time
- Start date: July 2022
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection
The role of CMC Project Manager is to provide CMC leadership to Resolution’s three lead therapeutic programmes. As a dedicated CMC leader, the person in this role will have considerable influence on the plans for providing product into clinical studies and building strategy for a robust commercial supply chain.
Key responsibilities
• At a project level, leads the cross functional CMC team including process development, analytical, manufacturing, supply chain, quality, and regulatory. Integrates individual CMC workstreams into an overall CMC delivery team
• Accountable for delivery of product to clinical studies and maintains and owns an overall CMC plan
• Accountable for developing a CMC budget and resource plan for each project and interfacing with the project leader and project manager to ensure CMC requirements and deliverables align with the overall project plan
• Developing a tech transfer plans into manufacturing and plans for a fit for purpose supply chain for clinical and commercial supply
• Key interface to the project team as the single point of CMC accountability influencing the project team regarding CMC requirements and influencing the CMC team regarding project requirements
• Influencing and educating other project team members (including investment stakeholders) in CMC priorities and interdependencies with other functions to ensure effective prioritisation
• As member of the CMC leadership team contributing to setting direction for the overall CMC effort in Resolution
The successful candidate will have the right to work in the UK, able to commute daily to Resolution Therapeutics in London and will have the following qualifications, skills and experience:
Your Experience
• At least 5 years’ (preferred >8 years) experience in CMC development, preferably in cell and gene therapy
• Exceptional matrix leadership capabilities especially as it related to influencing across the organisation and productive conflict resolution
• Organised leader that understands risk-based development and proactively manages and communicates CMC risks and mitigation plans
• Experienced with regulatory processes and understanding of phase appropriate development strategies
• A strategic thinker that can develop short- and long-term CMC plans and communicate them across the organisation
Your Qualifications
Basic
• A Bachelor of Science degree with relevant experience in process development, analytical, or manufacturing of biologics
• Project leadership of fast moving and complex projects in biotech or pharma
Desired
• An advanced degree in Biology, Chemistry, Chemical Engineering, Pharmacy, or related discipline
• Delivered a late-stage project into manufacturing and helped establish the associated supply chain for a cell and gene therapy medicine
Interested in the opportunity? To apply, click on the button below and send us your CV.
ApplyJOB TITLE: Research Associate - Cell Engineering
LOCATION: Edinburgh, UK
- Reporting to: Director of Cell Engineering and IPSC Biology
- Job type: Full time
- Start date: March 2022
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection.
We are looking for a Research Associate to join the fast-growing team within our Cell Engineering unit at our site in Edinburgh! This position is a full-time opportunity, on a permanent basis. In this role, you will carry out scientific discovery work relating to primary macrophages for therapeutic use in liver cirrhosis. Your responsibilities include:
• Identifying new candidates to produce clinically effective macrophages and improve transfection processes.
• Generating genetically modified macrophages through monocyte isolation, macrophage differentiation and macrophage transfection
• Maintaining excellent record keeping of all research activities, including up-to-date lab books, writing standard operating procedures, and cataloguing biological specimens and reagents
• Interfacing with the In vivo pharmacology, Macrophage Biology, and Induced Pluripotent Stem Cell units to refine enhanced macrophage candidates, and with the Process Development team to refine standard operating procedures and assist with implementation of GMP manufacturing process at scale
• Writing patents, publications and summarising data for progress reports and presentations; delivering presentations
Please note that this list is not exhaustive
You will be expected to work as part of a team with Research Scientists and Associates, reporting directly to the Director of Cell Engineering
The successful candidate is a detail oriented and thorough scientist, able to multi-task with a passion for scientific excellence and comfortable to working in a fast paced, dynamic and rapidly growing research environment. They will have the right to work in the UK, and will have the following qualifications, skills and experience:
Your Experience
Essential
• A bachelor’s degree in Biology, Biochemistry, or a related discipline
• Proven track record with at least 3 years’ experience working in an academic or industrial setting
• Experience with primary human immune cell culture, preferably monocytes/ macrophages
• Experience introducing genetic material into cells, using electroporation or multiple transfection methods, especially with difficult to transfect or primary cells.
• Experience with cell-based assays using flow cytometry and magnetic bead separation (MACS or similar)
• Experience in ELISA, PCR and qPCR
• Proven ability to work productively within a team
• Proven track record of independent manuscript publication and/or patent submission as a first author
• Ability to maintain accurate and up to date records
Preferred
• A working knowledge of chronic inflammatory diseases, preferably chronic liver disease
• Experience with gene expression assays and copy number analysis.
• Experience with high content imaging and analysis
• Experience working with rodent models of liver disease
• Knowledge of process development and analytics
• Genomic and transcriptomic analysis
• Experience with viral vectors; lentivirus or AAV
• Experience in a commercial laboratory environment
• Familiarity with the principles of Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP)
Interested in the opportunity? To apply, click on the button below and send us your CV.
ApplyJOB TITLE: Analytical Scientist - Translation
LOCATION: London, UK
- Reporting to: VP Analytics – Translation
- Job type: Full time
- Start date: ASAP
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection
We are offering an exciting opportunity for an experienced Analytical Scientist to join the fast-growing team in our Translation Group based in London. The position is a full-time opportunity, on a permanent basis.
In this role you will support the strategic and day-to-day analytical development program for engineered macrophage cell therapy products for therapeutic applications in liver cirrhosis. You will work very closely with the Edinburgh based units to translate assays as developed by R& to qualified assays suitable for routine QC testing according to GLP standards.
Specific responsibilities include:
• Accountable for the day-to-day in-process and final product testing required during the process development projects of the Translation Group
• Responsible for translation of research protocols to GLP compliant QC assays
• Responsible for development of assays and analytics to assess and confirm cell-based product characteristics and characterize genetically engineered macrophage candidates.
• Compilation of study protocols and reports associated with the development or characterisation of a cell-based or molecular assays
• Implement and tech transfer analytics to the GCLP lab for assessment of material intended for clinical use
• Accountable for the design of qualification and/or validation programs for QC assays
• Compilation of documentation for qualification or validation of assays
• Interfacing with CMOs for the qualification and / or validation of assays as part of the release strategy of cell therapy product(s)
• Establishment, development and execution of initial and ongoing stability studies
• Support the establishment of supply agreements with third-party testing laboratories
• Supporting the development of the Clinical Trial Dossier and regulatory-related documentation related to the analytical aspects of the cell therapy product(s), including risk assessments
• Writing patents, publications, data analysis and summarizing data for progress reports and presentations; delivering presentations
You will report directly to the VP Analytics, Translation and will collaborate closely with others within and beyond the Translation group.
The successful candidate will have the right to work in the UK, able to commute daily to Resolution Therapeutics in London and will have the following qualifications, skills and experience:
Your Experience
Essential
• A PhD degree / or equivalent experience in cell biology or immunology or a related discipline or equivalent experience
• Experience in Good Clinical Laboratory Practice (GCLP)
• 3 years’ academic as well as industry experience in analytics, including with stem cell derived and gene modified cell therapy products
• Experienced flow cytometry user including panel design, assay development, execution and data analysis
• Experience in development and execution of cell functionality assays
• Experience in development and execution of molecular techniques, such as PCR
• Experience with ELISA and MSD
• Data analysis and associated techniques
• Proven track record in development, qualification and validation of cell and gene-based assays
• Proven track record in documentation generation, including compilation of standard operating procedures and test protocols
• Proven track record with different primary cell types and associated culture techniques
• Proven ability to work productively within a team, with clear leadership skills
• Ability to maintain accurate and up to date records
Preferred
• A working knowledge of immunology and chronic inflammatory diseases, preferably chronic liver disease
• Experience Good Manufacturing Practice (GMP) settings
• Experience with analytical technology transfer
• Experience in development and execution of cytotoxicity assays
• Experience in genetic stability testing
• Experience developing advanced therapeutic medicinal products
• Experience using high throughput imaging e.g. Operetta
• Experience in a commercial laboratory environment
• Experience in a small biotechnology company
• Understanding Quality Management Systems
Interested in the opportunity? To apply, click on the button below and send us your CV.
ApplyJOB TITLE: VP Process Development - Translation
LOCATION: London, UK
- Reporting to: Chief Development Officer
- Job type: Full time
- Start date: ASAP
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection
We offer an exciting opportunity to join our fast-growing team as VP Process Development in our Translation Group, London. In this role you will be accountable for the process development program for engineered macrophage cell therapy products for therapeutic applications starting with liver cirrhosis. You will work very closely with the Edinburgh based units to develop, translate and optimize the process designs as developed by R&D to a qualified manufacturing design suitable for routine manufacturing according to GMP standards.
The Translation Group is focused on development, characterisation, qualification and/or validation of cell-based and molecular assays for testing of Clinical Trial Material manufactured under GMP conditions. The assays will be transferred, implemented and further developed from (1) the R&D macrophage biology department or (2) adapted as used in a previous Clinical Trial using a non-engineered macrophage product.
Specific responsibilities include:
• Leading the company’s Process Development group and activities
• As part of CMC leadership team provide strategic input into overall product development and manufacturing activities
• Provide guidance and invest in personal growth and development of process development staff
• Accountable to develop and execute a process development strategy that is phase appropriate for delivery of drug product through clinical phases and into commercialization
• Accountable to develop and execute a characterisation and qualification program to build product know-how related to identification of and criticality analysis for process parameters
• Manage the process development team of Scientists and Associates for development refinement and continuous improvement of the process, the unit operations, materials and process equipment used, including hands-on supporting data analysis and ad-hoc steering of experimental design and troubleshooting
• Accountable for translation of research protocols and interfacing with the Cell Engineering and Macrophage Biology Units to develop these standard operating procedures translating research protocols to the GMP environment
• Accountable for the qualification and validation program of the process
• Accountable for the documentation associated with the process development activities
• Accountable for technology transfer to CMO
• Accountable for the stability programs and generation of reference materials
• Responsible for supply agreements with outsourced suppliers
• Supporting the development of the Clinical Trial Dossier and regulatory-related documentation related to the analytical aspects of the cell therapy product(s), including QTPP, CTD, IMPD and risk assessments
• Writing patents, publications,
• Data analysis, definition of success criteria, summarizing data for progress reports and trending.
• Provide high level reports and presentations to be presented in management or board meetings
You will report directly to the Chief Development Officer and will build a team of scientists and associates that will grow with the progression of clinical programs. You will collaborate closely with Head of Analytical Development and Head of Quality within the Translation process group.
The successful candidate will have the right to work in the UK, and will have the following qualifications, skills and experience:
Your Experience
Essential
-
• A PhD degree / or equivalent experience in cell biology, chemical engineering, or immunology or a related discipline or equivalent experience
• Minimum 5 years’ industry experience in process development for ATMPs
• Proven track record in the biotech field, experience with working and delivering to company goals
• Ability and willingness to be actively involved in data analysis, interpretation and day-to-day management. Comfortable and able to bridge detailed data analysis to strategic and operational planning
• Proven ability to manage a team, with clear leadership skills
• Experience in Good Manufacturing Practice (GMP) settings
• An understanding of quality by design and developing an appropriate control strategy for products in development
• Proven track record of independent manuscript publication and/or patent submission as a first author
• Proven track record of experience with regulatory submissions through various phases of development and licensure
• Proven track record in documentation generation, including compilation of standard operating procedures and test protocols
• Proven track record with different primary cell types and associated culture techniques
• Experience with differentiation and/or proliferation of primary cell culture
• Experience with single-use, automated and closed processing techniques
• Experience with bioprocess engineering and scale-up cultivation
Preferred
-
• A working knowledge of immunology and chronic inflammatory diseases, preferably chronic liver disease
• Experience with technology transfer
• Experience in genetic stability testing
• Experience with flow cytometry techniques
• Understanding of aseptic processing
• Experience in a commercial laboratory environment
• Experience using cell processing equipment
• Experience with adherent and suspension bioreactor techniques
Interested in the opportunity? To apply, click on the button below and send us your CV.
ApplyJOB TITLE: Process Scientist - Translation
LOCATION: London, UK
- Reporting to: Group Leader – Translation
- Job type: Full time
- Start date: ASAP
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection
We offering an exciting opportunity for an experienced Process Development Scientist to join the fast-growing team within our Translation Group based in London. The position is a full-time opportunity, on a permanent contract. In this role you will support the day-to-day development of a process to produce genetically engineered macrophages for therapeutic applications in inflammatory organ damage. Your responsibilities include:
• Supporting development of a GMP compliant manufacturing process for engineered macrophage cell therapy
• Supporting optimisation of established processes suitable for transfer to GMP manufacturing environment
• Accountable to analyse and present process data for use in project reports and presentations
• Establishing and writing standard operating procedures from developed processes
• Working closely with Translation, Cell Engineering and Macrophage Biology units in Edinburgh to perform technology transfer from research to GMP-compliant processes, and subsequently from process development to manufacturing facility
• Responsibility for training and supporting technology transfer to GMP manufacturing facility
• Supervisory oversight of GMP activities in both manufacturing and Quality Assurance for example, compliance to Quality Management Systems, involvement in documentation preparation: risk assessments, change controls, non-conformance & CAPAs
• Supporting the development of the Clinical Trial Dossier and regulatory-related documentation
• Accountable for good documentation practices for data recording
• Liaising with external vendors and suppliers
• Writing patents, publications, data analysis and protocols, reports and compilation of presentations as well as delivering presentations
You will report directly to the Group Leader, Translation, and will collaborate closely with others within and beyond the Translation group.
The successful candidate will have the right to work in the UK, able to commute daily to Resolution Therapeutics in London and will have the following qualifications, skills and experience:
Your Experience
Essential
• A PhD degree / or equivalent experience in Biology, Biochemistry, or a related discipline or equivalent experience
• Experience in Good Manufacturing Practice (GMP)/Good Clinical Laboratory Practice (GCLP) settings
• Experience in cell therapy process development
• An understanding of quality by design and developing an appropriate control strategy for products in development
• Experience with different primary cell culture and different culture systems
• Experience using cell processing equipment, including the CliniMACS Prodigy instrument and/or similar equipment
• Experience with single-use, automated and closed processing techniques
• Experience with bioprocess engineering and scale-up cultivation
• Experience with adherent and suspension bioreactor techniques
• Proven ability to work productively within a team
• Ability to take initiative and work independently
• Excellent time management and organisation
• Confidence to communicate effectively and clearly both verbally and in writing
• Ability to maintain accurate and up to date records
Preferred
• A working knowledge of immunology and chronic inflammatory diseases, preferably chronic liver disease
• Experience in cell therapy process analytics
• Experience with multicolour cell flow cytometry and associated data analysis
• Experience with ELISA and MSD
• Experience with molecular techniques, such as PCR
• Understanding of Quality Management Systems
• Experience in a commercial laboratory environment
• Experience in biotechnology company
Interested in the opportunity? To apply, click on the button below and send us your CV.
ApplyJOB TITLE: Analytical Scientist - Translation
LOCATION: Edinburgh, UK
- Reporting to: Group Leader – Translation
- Job type: Full time
- Start date: ASAP
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection
We offer an exciting opportunity to join our fast-growing team as an Analytical Scientist in our Translation Group. In this role you will support the strategic and day-to-day development and implementation of assays and analytics characterising genetically engineered macrophages for therapeutic applications in liver cirrhosis. You will work very closely with the Scottish National Blood Transfusion Service (SNBTS), with which Resolution has partnered to deliver a gene-modified macrophage cell therapy for clinical use, to develop a GLP-suitable process.
The Translation Group is focused on development, characterisation, qualification and/or validation of cell-based and molecular assays for testing of Clinical Trial Material manufactured under GMP conditions. The assays will be transferred, implemented and further developed from (1) the R&D macrophage biology department or (2) adapted as used in a previous Clinical Trial using a non-engineered macrophage product.
Specific responsibilities include:
• Supporting the day-to-day in-process and final product analytical testing required during the process development projects of the Translation Group
• Development of assays and analytics to assess and confirm cell-based product characteristics
• Development and refinement of assays and analytics to characterise genetically engineered macrophage product candidates
• Establishment, development and execution of stability studies
• Interfacing with the Cell Engineering and Macrophage Biology Units to translate research protocols and develop standard operating procedures for the GLP environment
• Interfacing with SNBTS for the qualification and / or validation of assays as part of the release strategy of the macrophage gene-modified macrophage cell therapy
• Supporting development of an end-to-end GMP/GLP production process and testing profile
• Implement analytics in the GCLP lab for assessment of material intended for clinical use
• Compilation of study protocols and reports associated with the development or characterisation of a cell-based or molecular assay
• Compilation of documentation for qualification or validation of assays
• Support the establishment of supply agreements with third-party test labs
• Supporting the development of the Clinical Trial Dossier and regulatory-related documentation related to the analytical aspects of the gene-engineered macrophage cell therapy, including risk assessments
• Writing patents, publications, data analysis and summarising data for progress reports and presentations; delivering presentations
You will report directly to the Group Leader, Translation and will collaborate closely with others within and beyond the Translation group.
The successful candidate will have the right to work in the UK, able to commute daily to Resolution Therapeutics in Edinburgh and will have the following qualifications, skills and experience:
Your Experience
Essential
-
- • A MSc in cell biology or immunology
-
- • 3 years’ academic as well as industry experience in analytics, including with gene- modified cell therapy products
-
- • Experience in Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) settings
-
- • Proven track record in development, qualification and validation of cell and gene-based assays
-
- • Proven track record with different primary cell types and associated culture techniques
-
- • Proven track record in documentation generation, including compilation of standard operating procedures and test protocols
-
- • Data analysis and associated techniques
-
- • Experience with flow cytometry and magnetic bead separation (MACS or similar)
-
- • Experience with analytical technology transfer
-
- • Proven ability to work productively within a team, with clear leadership skills
• Ability to maintain accurate and up to date records
Preferred
-
- • A working knowledge of immunology and chronic inflammatory diseases, preferably chronic liver disease
-
- • Experience developing cell therapies
-
- • Experience using the CliniMACS Prodigy instrument and associated equipment
-
- • Experience in a commercial laboratory environment
• Experience in a small biotechnology company
Interested in the opportunity? To apply, click on the button below and send us your CV.
ApplyJOB TITLE: Research Associate, Induced Pluripotent Stem Cells
LOCATION: Edinburgh, UK
- Reporting to: Director of Cell Engineering and IPSC Biology
- Job type: Full time
- Start date: March 2022
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection.
We offer an exciting opportunity to join our fast-growing team as a Research Associate within our Induced Pluripotent Stem Cells unit. In this role, you will carry out scientific discovery work relating to iPSC-derived macrophages for therapeutic use in liver cirrhosis. Your responsibilities include:
• iPSC culture and characterization
• Develop and optimize protocols for macrophage differentiation
• Supporting the engineering of iPSCs and derived macrophages e.g., for hypo-immunogenicity, as well as introduction of phenotype enhancing payloads
• Supporting the scale-up efforts using multiple culturing formats
• Interfacing with the Cell Engineering, In Vivo Pharmacology, Translational and Macrophage Biology units to identify best-in-class iMACs products and collaborate on assay development, scale-up and in vivo studies
• Assisting with writing patents, publications and summarising data for progress reports and presentations
• General laboratory management and instrument maintenance duties
You will report directly to the Director of Cell Engineering and iPSC Biology and will collaborate closely with other scientists and associates in the iPSC Biology unit.
The successful candidate is a detail oriented and thorough scientist, able to multi-task with a passion for scientific excellence and comfortable to working in a fast paced, dynamic and rapidly growing research environment. They will have the right to work in the UK, and will have the following qualifications, skills and experience:
Your Experience
Essential
• A bachelor’s degree in Biology, Biochemistry, or a related discipline
• Proven track record with at least 3 years’ experience working in an academic or industrial setting
• Experience with stem cells, including their characterization and differentiation into desired target cell types
• Experience with cell-based assays using flow cytometry and magnetic bead separation (MACS or similar)
• Experience with primary immune cell culture, preferably monocytes/macrophages
• Experience in molecular biology techniques such as nucleic acid extraction and purification, PCR and qPCR
• Experience in western blotting, ELISA, immunofluorescence and immunohistochemistry
• Ability to maintain accurate and up to date records, as proven by a track record of publications as co-author
Preferred
• Experience working with iPSCs and differentiation
• Knowledge of cell engineering techniques
• A working knowledge of inflammation and chronic liver disease
• Experience with cloning and transfection
• Familiarity with the principles of Good Clinical Practice (GCP) and Good Manufacturing Practice (GMP) and writing of standard operating procedures
Interested in the opportunity? To apply, click on the button below and send us your CV.
ApplyJOB TITLE: Research Scientist - Cell Engineering
LOCATION: Edinburgh, UK
- Reporting to: Director of Cell Engineering
- Job type: Full time
- Start date: March 2022
- Incentives: An opportunity to participate in the Company’s incentive share scheme
- Benefits: Competitive package including pension, private health insurance, life assurance and income protection.
We offer an exciting opportunity to join our fast-growing team as a Research Scientist within our Cell Engineering unit. In this role, you will take the lead in producing and studying enhanced macrophage products for cell therapy for liver cirrhosis. Specific responsibilities include:
• Identifying new candidates to produce clinically effective macrophages and improve transfection processes.
• Generating genetically modified macrophages through monocyte isolation, macrophage differentiation and macrophage transfection
• Generating genetically modified iPSC derived macrophages (iMACs)
• Maintaining excellent record keeping of all research activities, including up-to-date lab books, writing standard operating procedures, and cataloguing biological specimens and reagents
• Interfacing with the In vivo pharmacology, Macrophage Biology, and Induced Pluripotent Stem Cell units to refine enhanced macrophage candidates, and with the Process Development team to refine standard operating procedures and assist with implementation of GMP manufacturing process at scale
• Writing patents, publications and summarising data for progress reports and presentations; delivering presentations
You will report directly to the Director of Cell Engineering and will collaborate closely with other scientists and associates in the Cell Engineering unit.
The successful candidate is a detail oriented and thorough scientist, able to multi-task with a passion for scientific excellence and comfortable to working in a fast paced, dynamic and rapidly growing research environment. They will have the right to work in the UK, and will have the following qualifications, skills and experience
Your Experience
Essential
- • A PhD in molecular biology, biochemistry, cell biology or equivalent experience
• Experience with primary human immune cell culture, preferably monocytes/ macrophages
• Experience in genetic modification of primary cells and/or iPSCs
• Experience with one or more gene-editing techniques: CRISPR, TALEN, ZNF nucleases
• Experience with gRNA design and vector design.
• Experience with antibody-based sorting and analysis using flow cytometry and magnetic bead separation and analysis
• Experience with multiple transfection methods, especially with difficult to transfect or primary cells.
• Experience in western blotting, ELISA, qPCR and ddPCR
• Experience with gene expression assays and copy number analysis.
• Experience with high content imaging and analysis
• Proven ability to work productively within a team
• Ability to maintain accurate and up to date records
• Proven track record of independent manuscript publication and/or patent submission as a first author
Preferred
- • 2+ years’ relevant postdoctoral academic and/or industry experience
• A working knowledge of chronic inflammatory diseases, preferably chronic liver disease
• Experience working with rodent models of liver disease
• Knowledge of process development and analytics
• Genomic and transcriptomic analysis
• Single-cell analysis
• Experience with viral vectors; lentivirus or AAV
• Experience in a commercial laboratory environment
• Familiarity with the principles of Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP)
Interested in the opportunity? To apply, click on the button below and send us your CV.
Apply